A residue in the intracellular vestibule of the pore is critical for gating and permeation in Ca(2+)-activated K(+) (BK(Ca)) channels

1. We have used patch clamp to record large-conductance Ca(2+)-activated K(+) (BK(Ca)) currents from a human embryonic kidney cell line (HEK293) expressing wild-type and mutant hSloα channels. 2. When we mutated F380 in the S6 region, thought to contribute to the intracellular vestibule of the pore,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lippiat, J D, Standen, N B, Davies, N W
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Science Inc 2000
Pynciau:
Rapid Report
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2270189/
https://ncbi.nlm.nih.gov/pubmed/11080257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.2000.00131.x
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