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Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons

1. Glutamate neurotoxicity has been attributed to cellular Ca(2+) overload. As mitochondrial depolarisation may represent a pivotal step in the progression to cell death, we have used digital imaging techniques to examine the relationship between cytosolic Ca(2+) concentration ([Ca(2+)](c)) and mito...

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Autors principals: Keelan, Julie, Vergun, Olga, Duchen, Michael R
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269623/
https://ncbi.nlm.nih.gov/pubmed/10545145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.00797.x
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