Local regulation of the threshold for calcium sparks in rat ventricular myocytes: role of sodium-calcium exchange

1. To determine whether Na(+)-Ca(2+) exchange modulates Ca(2+) sparks, we studied enzymatically isolated patch clamped rat ventricular myocytes loaded with the Ca(2+)-sensitive indicator fluo-3, using confocal microscopy at 20–22 °C. Two-dimensional images of Ca(2+) sparks were recorded at 240 Hz us...

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Bibliografiske detaljer
Main Authors: Goldhaber, Joshua I, Lamp, Scott T, Walter, Donald O, Garfinkel, Alan, Fukumoto, Gary H, Weiss, James N
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 1999
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2269602/
https://ncbi.nlm.nih.gov/pubmed/10523412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7793.1999.00431.x
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