Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma

Apolipoprotein E- (apoE) deficient (E(−/−)) mice develop severe hyperlipidemia and diffuse atherosclerosis. Low-dose expression of a human apoE3 transgene in macrophages of apoE-deficient mice (E(−/−)hTgE(+/0)), which results in about 5% of wild-type apoE plasma levels, did not correct hyperlipidemi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Zhu, Yenhong, Bellosta, Stefano, Langer, Claus, Bernini, Franco, Pitas, Robert E., Mahley, Robert W., Assmann, Gerd, von Eckardstein, Arnold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22691/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636193/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7585
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