Low-dose expression of a human apolipoprotein E transgene in macrophages restores cholesterol efflux capacity of apolipoprotein E-deficient mouse plasma

Apolipoprotein E- (apoE) deficient (E(−/−)) mice develop severe hyperlipidemia and diffuse atherosclerosis. Low-dose expression of a human apoE3 transgene in macrophages of apoE-deficient mice (E(−/−)hTgE(+/0)), which results in about 5% of wild-type apoE plasma levels, did not correct hyperlipidemi...

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Main Authors: Zhu, Yenhong, Bellosta, Stefano, Langer, Claus, Bernini, Franco, Pitas, Robert E., Mahley, Robert W., Assmann, Gerd, von Eckardstein, Arnold
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 1998
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC22691/
https://ncbi.nlm.nih.gov/pubmed/9636193
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