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Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth

Leishmania is unable to synthesize heme and must acquire it from exogenous source, the mechanism of which is not known. We have shown that Leishmania endocytoses hemoglobin (Hb) and subsequently degrade it probably to generate heme. To understand how internalized Hb is degraded, we have cloned and e...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Patel, Nitin, Singh, Sudha B., Basu, Sandip K., Mukhopadhyay, Amitabha
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2008
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268841/
https://ncbi.nlm.nih.gov/pubmed/18319337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800404105
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