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Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth
Leishmania is unable to synthesize heme and must acquire it from exogenous source, the mechanism of which is not known. We have shown that Leishmania endocytoses hemoglobin (Hb) and subsequently degrade it probably to generate heme. To understand how internalized Hb is degraded, we have cloned and e...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268841/ https://ncbi.nlm.nih.gov/pubmed/18319337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800404105 |
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