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Gating-associated conformational changes in the mechanosensitive channel MscL

Bacterial cells avoid lysis in response to hypoosmotic shock through the opening of the mechanosensitive channel MscL. Upon channel opening, MscL is thought to expand in the plane of the membrane and form a large pore with an estimated diameter of 3–4 nm. Here, we set out to analyze the closed and o...

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Autori principali: Yoshimura, Kenjiro, Usukura, Jiro, Sokabe, Masahiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268802/
https://ncbi.nlm.nih.gov/pubmed/18310324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709436105
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