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Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

BACKGROUND: Aspartyl protease inhibitors (PIs) used to treat HIV belong to an important group of drugs that influence significantly endothelial cell functioning and angiogenic capacity, although specific mechanisms are poorly understood. Recently, PIs, particularly Nelfinavir, were reported to disru...

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Main Authors: Grigorian, Aline, Hurford, Rosemary, Chao, Ying, Patrick, Christina, Langford, T Dianne
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268698/
https://ncbi.nlm.nih.gov/pubmed/18302767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2202-9-27
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