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Control of Virus-Specific CD8(+) T-Cell Exhaustion and Immune-Mediated Pathology by E3 Ubiquitin Ligase Cbl-b during Chronic Viral Infection

A characteristic feature in the immune response to many persistent viral infections is the dysfunction or deletion of antigen-specific T cells (exhaustion). This down-regulation of virus-specific T-cell response represents a critical control mechanism that exists within T-cell activation pathways to...

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Bibliografiske detaljer
Main Authors: Ou, Rong, Zhang, Menghua, Huang, Lei, Moskophidis, Demetrius
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268476/
https://ncbi.nlm.nih.gov/pubmed/18199651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01350-07
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