Trio Mediates Netrin-1-Induced Rac1 Activation in Axon Outgrowth and Guidance

The chemotropic guidance cue netrin-1 promotes neurite outgrowth through its receptor Deleted in Colorectal Cancer (DCC) via activation of Rac1. The guanine nucleotide exchange factor (GEF) linking netrin-1/DCC to Rac1 activation has not yet been identified. Here, we show that the RhoGEF Trio mediat...

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Detalhes bibliográficos
Main Authors: Briançon-Marjollet, Anne, Ghogha, Atefeh, Nawabi, Homaira, Triki, Ibtissem, Auziol, Camille, Fromont, Sylvie, Piché, Chantal, Enslen, Hervé, Chebli, Karim, Cloutier, Jean-François, Castellani, Valérie, Debant, Anne, Lamarche-Vane, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268419/
https://ncbi.nlm.nih.gov/pubmed/18212043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00998-07
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