Homologous Recombination Is Necessary for Normal Lymphocyte Development

Primary immunodeficiencies are rare but serious diseases with diverse genetic causes. Accumulating evidence suggests that defects in DNA double-strand break (DSB) repair can underlie many of these syndromes. In this context, the nonhomologous end joining pathway of DSB repair is absolutely required...

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Bibliographic Details
Main Authors: Caddle, Lura B., Hasham, Muneer G., Schott, William H., Shirley, Bobbi-Jo, Mills, Kevin D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268416/
https://ncbi.nlm.nih.gov/pubmed/18212067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02139-07
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