Survival Signaling by C-RAF: Mitochondrial Reactive Oxygen Species and Ca(2+) Are Critical Targets

Survival signaling by RAF occurs through largely unknown mechanisms. Here we provide evidence for the first time that RAF controls cell survival by maintaining permissive levels of mitochondrial reactive oxygen species (ROS) and Ca(2+). Interleukin-3 (IL-3) withdrawal from 32D cells resulted in ROS...

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Detalhes bibliográficos
Main Authors: Kuznetsov, Andrey V., Smigelskaite, Julija, Doblander, Christine, Janakiraman, Manickam, Hermann, Martin, Wurm, Martin, Scheidl, Stefan F., Sucher, Robert, Deutschmann, Andrea, Troppmair, Jakob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268412/
https://ncbi.nlm.nih.gov/pubmed/18212057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00683-07
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