Loss of Singleminded-2s in the Mouse Mammary Gland Induces an Epithelial-Mesenchymal Transition Associated with Up-Regulation of Slug and Matrix Metalloprotease 2

The short splice variant of the basic helix-loop-helix Per-Arnt-Sim transcription factor Singleminded-2, SIM2s, has been implicated in development and is frequently lost or reduced in primary breast tumors. Here, we show that loss of Sim2s causes aberrant mouse mammary gland ductal development with...

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Bibliographic Details
Main Authors: Laffin, Brian, Wellberg, Elizabeth, Kwak, Hyeong-Il, Burghardt, Robert C., Metz, Richard P., Gustafson, Tanya, Schedin, Pepper, Porter, Weston W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268409/
https://ncbi.nlm.nih.gov/pubmed/18160708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01701-07
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