Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin Reorganization

We have analyzed the means by which the Nck family of adaptor proteins couples adhesion proteins to actin reorganization. The nephrin adhesion protein is essential for the formation of actin-based foot processes in glomerular podocytes. The clustering of nephrin induces its tyrosine phosphorylation,...

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Autori principali: Blasutig, Ivan M., New, Laura A., Thanabalasuriar, Ajitha, Dayarathna, Thamara K., Goudreault, Marilyn, Quaggin, Susan E., Li, Shawn S.-C., Gruenheid, Samantha, Jones, Nina, Pawson, Tony
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268406/
https://ncbi.nlm.nih.gov/pubmed/18212058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01770-07
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