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Chemically modified β-glucuronidase crosses blood–brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII
Enzyme replacement therapy has been used successfully in many lysosomal storage diseases. However, correction of brain storage has been limited by the inability of infused enzyme to cross the blood–brain barrier. The newborn mouse is an exception because recombinant enzyme is delivered to neonatal b...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268185/ https://ncbi.nlm.nih.gov/pubmed/18268347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0712147105 |
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