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Conformational changes in G-protein-coupled receptors—the quest for functionally selective conformations is open
The G-protein-coupled receptors (GPCRs) represent one the largest families of drug targets. Upon agonist binding a receptor undergoes conformational rearrangements that lead to a novel protein conformation which in turn can interact with effector proteins. During the last decade significant progress...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2268050/ https://ncbi.nlm.nih.gov/pubmed/18059316 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707615 |
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