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Phosphorylation and ubiquitination of oncogenic mutants of β-catenin containing substitutions at Asp32
β-Catenin, a member of the Wnt signaling pathway, is downregulated by glycogen synthase kinase-3β (GSK-3β)-dependent phosphorylation of Ser/Thr residues in the N-terminus of the protein, followed by ubiquitination and proteosomal degradation. In human and rodent cancers, mutations that substitute on...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267883/ https://ncbi.nlm.nih.gov/pubmed/15064718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1207634 |
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