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AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene
Somatic hypermutation (SHM) and gene conversion (GCV) are closely related processes that increase the diversity the primary immunoglobulin repertoire. In both processes the activation-induced cytidine deaminase (AID) converts cytosine residues to uracils within the DNA of the immunoglobulin (Ig) gen...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2267867/ https://ncbi.nlm.nih.gov/pubmed/18023479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2007.10.017 |
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