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A Marked Effect of Electroconvulsive Stimulation on Behavioral Aberration of Mice with Neuron-Specific Mitochondrial DNA Defects

We developed transgenic (Tg) mice modeling an autosomally inherited mitochondrial disease, chronic progressive external ophthalmoplegia, patients with which sometimes have comorbid mood disorders. The mutant animals exhibited bipolar disorder-like phenotypes, such as a distorted day–night rhythm and...

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Autors principals: Kasahara, Takaoki, Kubota, Mie, Miyauchi, Taeko, Ishiwata, Mizuho, Kato, Tadafumi
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267493/
https://ncbi.nlm.nih.gov/pubmed/18365022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001877
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