Effect of bradykinin metabolism inhibitors on evoked hypotension in rats: rank efficacy of enzymes associated with bradykinin-mediated angioedema

BACKGROUND AND PURPOSE: Inhibition of bradykinin metabolizing enzymes (BMEs) can cause acute angioedema, as demonstrated in a recent clinical trial in patients administered the antihypertensive, omapatrilat. However, the relative contribution of specific BMEs to this effect is unclear and confounded...

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Detalhes bibliográficos
Main Authors: Fryer, R M, Segreti, J, Banfor, P N, Widomski, D L, Backes, B J, Lin, C W, Ballaron, S J, Cox, B F, Trevillyan, J M, Reinhart, G A, von Geldern, T W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267285/
https://ncbi.nlm.nih.gov/pubmed/18084312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707641
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