Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A(4) hydrolase

BACKGROUND AND PURPOSE: Leukotriene B(4) (LTB(4)), formed by the sequential actions of the 5-lipoxygenase (5-LO) and leukotriene A(4) hydrolase (LTA(4)H), is a pro-inflammatory mediator implicated in the pathogenesis of inflammatory bowel disease. However, inhibitors of 5-LO have not proved to be co...

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Detalhes bibliográficos
Main Authors: Whittle, B J R, Varga, C, Berko, A, Horvath, K, Posa, A, Riley, J P, Lundeen, K A, Fourie, A M, Dunford, P J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267273/
https://ncbi.nlm.nih.gov/pubmed/18157165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707645
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