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IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice

A hallmark of SLE is the production of high-titer, high-affinity, isotype-switched IgG autoantibodies directed against nucleic acid–associated antigens. Several studies have established a role for both type I IFN (IFN-I) and the activation of TLRs by nucleic acid–associated autoantigens in the patho...

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Detalhes bibliográficos
Main Authors: Thibault, Donna L., Chu, Alvina D., Graham, Kareem L., Balboni, Imelda, Lee, Lowen Y., Kohlmoos, Cassidy, Landrigan, Angela, Higgins, John P., Tibshirani, Robert, Utz, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267033/
https://ncbi.nlm.nih.gov/pubmed/18340381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30065
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