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The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin

Most patients (80%) with ovarian cancer (OvCa) present with metastatic disease. Attachment of OvCa cells to peritoneum and omentum represents the first rate-limiting step for metastatic spread. Therefore, identifying factors regulating cell attachment in the abdominal cavity is critical to the devel...

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Autors principals: Kenny, Hilary A., Kaur, Swayamjot, Coussens, Lisa M., Lengyel, Ernst
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2267016/
https://ncbi.nlm.nih.gov/pubmed/18340378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI33775
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