SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

SEK1 (MKK4/JNKK) is a mitogen-activated protein kinase activator that has been shown to participate in vitro in two stress-activated cascades terminating with the SAPK and p38 kinases. To define the role of SEK1 in vivo, we studied stress-induced signaling in SEK1(−/−) embryonic stem and fibroblast...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Ganiatsas, Soula, Kwee, Lia, Fujiwara, Yuko, Perkins, Andrew, Ikeda, Tohru, Labow, Mark A., Zon, Leonard I.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22670/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9618507/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.12.6881
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