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Modulation of Ca(V)1.2 Channels by Mg(2+) Acting at an EF-hand Motif in the COOH-terminal Domain
Magnesium levels in cardiac myocytes change in cardiovascular diseases. Intracellular free magnesium (Mg(i)) inhibits L-type Ca(2+) currents through Ca(V)1.2 channels in cardiac myocytes, but the mechanism of this effect is unknown. We hypothesized that Mg(i) acts through the COOH-terminal EF-hand o...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2266622/ https://ncbi.nlm.nih.gov/pubmed/16157690 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509333 |
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