Hemoglobin binding to Aβ and HBG2 SNP association suggest a role in Alzheimer's disease

From a normal human brain phage display library screen we identified the gamma (A)-globin chain of fetal hemoglobin (Hb F) as a protein that bound strongly to Aβ1-42. We showed the oxidized form of adult Hb (metHb A) binds with greater affinity to Aβ1-42 than metHb F. MetHb is more toxic than oxyhem...

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Huvudupphovsmän: Perry, Rodney T., Gearhart, Debra A., Wiener, Howard W., Harrell, Lindy E., Barton, James C., Kutlar, Abdullah, Kutlar, Ferdane, Ozcan, Ozan, Go, Rodney C. P., Hill, William D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2006
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266611/
https://ncbi.nlm.nih.gov/pubmed/17157413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2006.10.017
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