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Phospholipase C in Living Cells: Activation, Inhibition, Ca(2+) Requirement, and Regulation of M Current

We have further tested the hypothesis that receptor-mediated modulation of KCNQ channels involves depletion of phosphatidylinositol 4,5-bisphosphate (PIP(2)) by phosphoinositide-specific phospholipase C (PLC). We used four parallel assays to characterize the agonist-induced PLC response of cells (ts...

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Detalhes bibliográficos
Main Authors: Horowitz, Lisa F., Hirdes, Wiebke, Suh, Byung-Chang, Hilgemann, Donald W., Mackie, Ken, Hille, Bertil
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266577/
https://ncbi.nlm.nih.gov/pubmed/16129772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509309
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