Interleukin-6 is responsible for aberrant B-cell receptor-mediated regulation of RAG expression in systemic lupus erythematosus

Defective regulation of secondary immunoglobulin V(D)J gene rearrangement promotes the production of autoantibodies in systemic lupus erythematosus (SLE). It remains unclear, however, whether the regulation of the recombination-activating genes RAG1 and RAG2 is effective in SLE. RAG1 and RAG2 messen...

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Autori principali: Hillion, Sophie, Garaud, Soizic, Devauchelle, Valérie, Bordron, Anne, Berthou, Christian, Youinou, Pierre, Jamin, Christophe
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2007
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266017/
https://ncbi.nlm.nih.gov/pubmed/17608810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02649.x
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