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p73 poses a barrier to malignant transformation by limiting anchorage-independent growth
p53 is known to prevent tumour formation by restricting the proliferation of damaged or oncogene-expressing cells. In contrast, how the p53 family member p73 suppresses tumour formation remains elusive. Using a step-wise transformation protocol for human cells, we show that, in premalignant stages,...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265751/ https://ncbi.nlm.nih.gov/pubmed/18239687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.13 |
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