p73 poses a barrier to malignant transformation by limiting anchorage-independent growth

p53 is known to prevent tumour formation by restricting the proliferation of damaged or oncogene-expressing cells. In contrast, how the p53 family member p73 suppresses tumour formation remains elusive. Using a step-wise transformation protocol for human cells, we show that, in premalignant stages,...

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Main Authors: Beitzinger, Michaela, Hofmann, Lars, Oswald, Claudia, Beinoraviciute-Kellner, Rasa, Sauer, Markus, Griesmann, Heidi, Bretz, Anne Catherine, Burek, Christof, Rosenwald, Andreas, Stiewe, Thorsten
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265751/
https://ncbi.nlm.nih.gov/pubmed/18239687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.13
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