A phase I clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic/necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10 -1082 promoter genotype as predictor of disease progression

BACKGROUND: Sixteen melanoma patients (1 stage IIC, 8 stage III, and 7 stage IV) were treated in a Phase I study with a vaccine (DC/Apo-Nec) composed of autologous dendritic cells (DCs) loaded with a mixture of apoptotic/necrotic allogeneic melanoma cell lines (Apo-Nec), to evaluate toxicity and imm...

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Autores principales: von Euw, Erika M, Barrio, María M, Furman, David, Levy, Estrella M, Bianchini, Michele, Peguillet, Isabelle, Lantz, Olivier, Vellice, Alejandra, Kohan, Abraham, Chacón, Matías, Yee, Cassian, Wainstok, Rosa, Mordoh, José
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265680/
https://ncbi.nlm.nih.gov/pubmed/18221542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-6-6
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