A Systematic Genetic Assessment of 1,433 Sequence Variants of Unknown Clinical Significance in the BRCA1 and BRCA2 Breast Cancer–Predisposition Genes

Mutation screening of the breast and ovarian cancer–predisposition genes BRCA1 and BRCA2 is becoming an increasingly important part of clinical practice. Classification of rare nontruncating sequence variants in these genes is problematic, because it is not known whether these subtle changes alter f...

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Bibliografiska uppgifter
Huvudupphovsmän: Easton, Douglas F. , Deffenbaugh, Amie M. , Pruss, Dmitry , Frye, Cynthia , Wenstrup, Richard J. , Allen-Brady, Kristina , Tavtigian, Sean V. , Monteiro, Alvaro N. A. , Iversen, Edwin S. , Couch, Fergus J. , Goldgar, David E. 
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Human Genetics 2007
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265654/
https://ncbi.nlm.nih.gov/pubmed/17924331
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