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Role of Duplicate Genes in Robustness against Deleterious Human Mutations

It is now widely recognized that robustness is an inherent property of biological systems [1],[2],[3]. The contribution of close sequence homologs to genetic robustness against null mutations has been previously demonstrated in simple organisms [4],[5]. In this paper we investigate in detail the con...

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Main Authors: Hsiao, Tzu-Lin, Vitkup, Dennis
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265532/
https://ncbi.nlm.nih.gov/pubmed/18369440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000014
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