Defective integration of activating signals derived from the T cell receptor (TCR) and costimulatory molecules in both CD4(+) and CD8(+) T lymphocytes of common variable immunodeficiency (CVID) patients

CVID is characterized by hypogammaglobulinaemia and impaired antibody production. Previous studies demonstrated defects at the T cell level. In the present study the response of purified CD4(+) and CD8(+) T lymphocytes to stimulation with anti-TCR monoclonal antibody (the first signal) in combinatio...

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Detalhes bibliográficos
Main Authors: THON, V, WOLF, H M, SASGARY, M, LITZMAN, J, SAMSTAG, A, HAUBER, I, LOKAJ, J, EIBL, M M
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 1997
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265506/
https://ncbi.nlm.nih.gov/pubmed/9367399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.1997.tb08314.x
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