Defective CD2 T cell pathway activation in common variable immunodeficiency (CVID).

Clonal T cell expansion requires simultaneous activation of the TCR and secondary signals, e.g. CD2, CD4, CD28. Interference of CD2/CD58 interaction with MoAbs abrogates the primary immune response and antibody production. Given this functional importance of CD2/CD58 interaction for the generation o...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Zielen, S, Dengler, T J, Bauscher, P, Meuer, S C
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1994
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1534907/
https://ncbi.nlm.nih.gov/pubmed/7910535
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