NFAT but not NF-κB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

FcϵRI-activation–induced survival of mast cells is dependent on the expression and function of the prosurvival protein A1. The expression of A1 in lymphocytes and monocytes has previously been described to be transcriptionally regulated by NF-κB. Here we demonstrate that the expression of A1 in mast...

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Autori principali: Ullerås, Erik, Karlberg, Mats, Möller Westerberg, Christine, Alfredsson, Jessica, Gerondakis, Steve, Strasser, Andreas, Nilsson, Gunnar
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2008
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265451/
https://ncbi.nlm.nih.gov/pubmed/18182578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-053371
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