MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation

In response to Toll-like receptor ligands, dendritic cells (DCs) dramatically enhance their antigen presentation capacity by stabilizing at the cell-surface MHC II molecules. We demonstrate here that, in human monocyte-derived DCs, the RING-CH ubiquitin E3 ligase, membrane-associated RING-CH I (MARC...

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Bibliographische Detailangaben
Hauptverfasser: De Gassart, Aude, Camosseto, Voahirana, Thibodeau, Jacques, Ceppi, Maurizio, Catalan, Nadia, Pierre, Philippe, Gatti, Evelina
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265198/
https://ncbi.nlm.nih.gov/pubmed/18305173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708874105
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