Engineering of mucin-type human glycoproteins in yeast cells

Mucin-type O-glycans are the most typical O-glycans found in mammalian cells and assume many different biological roles. Here, we report a genetic engineered yeast strain capable of producing mucin-type sugar chains. Genes encoding Bacillus subtilis UDP-Gal/GalNAc 4-epimerase, human UDP-Gal/GalNAc t...

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Detalhes bibliográficos
Main Authors: Amano, Koh, Chiba, Yasunori, Kasahara, Yoshiko, Kato, Yukinari, Kaneko, Mika Kato, Kuno, Atsushi, Ito, Hiromi, Kobayashi, Kazuo, Hirabayashi, Jun, Jigami, Yoshifumi, Narimatsu, Hisashi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265114/
https://ncbi.nlm.nih.gov/pubmed/18296643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710412105
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