Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer

Progress toward understanding the pathogenesis of cystic fibrosis (CF) and developing effective therapies has been hampered by lack of a relevant animal model. CF mice fail to develop the lung and pancreatic disease that cause most of the morbidity and mortality in patients with CF. Pigs may be bett...

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Auteurs principaux: Rogers, Christopher S., Hao, Yanhong, Rokhlina, Tatiana, Samuel, Melissa, Stoltz, David A., Li, Yuhong, Petroff, Elena, Vermeer, Daniel W., Kabel, Amanda C., Yan, Ziying, Spate, Lee, Wax, David, Murphy, Clifton N., Rieke, August, Whitworth, Kristin, Linville, Michael L., Korte, Scott W., Engelhardt, John F., Welsh, Michael J., Prather, Randall S.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2008
Sujets:
Technical Advance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265103/
https://ncbi.nlm.nih.gov/pubmed/18324337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34773
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