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Cooperative α-helix unfolding in a protein–DNA complex from hydrogen–deuterium exchange
We present experimental evidence for a cooperative unfolding transition of an α-helix in the lac repressor headpiece bound to a symmetric variant of the lac operator, as inferred from hydrogen–deuterium (H–D) exchange experiments monitored by NMR spectroscopy. In the EX1 limit, observed exchange rat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265102/ https://ncbi.nlm.nih.gov/pubmed/16751603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051938006 |
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