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Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein

The SCF ubiquitin ligase complex of budding yeast triggers DNA replication by catalyzing ubiquitination of the S phase cyclin-dependent kinase inhibitor SIC1. SCF is composed of three proteins—ySKP1, CDC53 (Cullin), and the F-box protein CDC4—that are conserved from yeast to humans. As part of an ef...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lyapina, Svetlana A., Correll, Craig C., Kipreos, Edward T., Deshaies, Raymond J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22647/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9636170/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.13.7451
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