The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition

We have shown that Wnt5A increases the motility of melanoma cells. To explore cellular pathways involving Wnt5A, we compared gain-of-function (WNT5A stable transfectants) versus loss-of-function (siRNA knockdown) of WNT5A by microarray analysis. Increasing WNT5A suppressed the expression of several...

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Detalhes bibliográficos
Main Authors: Dissanayake, Samudra K., Wade, Michael, Johnson, Carrie E., O’Connell, Michael P., Leotlela, Poloko D., French, Amanda D., Shah, Kavita V., Hewitt, Kyle J., Rosenthal, Devin T., Indig, Fred E., Jiang, Yuan, Nickoloff, Brian J., Taub, Dennis D., Trent, Jeffrey M., Moon, Randall T., Bittner, Michael, Weeraratna, Ashani T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2263117/
https://ncbi.nlm.nih.gov/pubmed/17426020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M700075200
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