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Carglumic acid: an additional therapy in the treatment of organic acidurias with hyperammonemia?
BACKGROUND: Hyperammonemia in patients with methylmalonic aciduria (MMA) and propionic aciduria (PA) is caused by accumulation of propionyl-CoA which decreases the synthesis of N-acetyl-glutamate, the natural activator of carbamyl phosphate synthetase 1. A treatment approach with carglumic acid, the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2262878/ https://ncbi.nlm.nih.gov/pubmed/18234091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-3-2 |
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