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Dynamics of Saxitoxin Binding to Saxiphilin C-lobe Reveals Conformational Change

Thermodynamic parameters (ΔG, ΔH, ΔS, ΔC(p)) have been determined to evaluate the dynamics of binding of saxitoxin to the c-lobe of saxiphilin. We have developed an improved method to rapidly express and purify recombinant saxiphilin c-lobe, and fully characterized it by mass spectrometry for the fi...

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Detalhes bibliográficos
Main Authors: Lewis, Penny, Fritsch, Ingrid, Gawley, Robert E., Henry, Ralph, Kight, Alicia, Lay, Jackson O., Liyanage, Rohana, McLachlin, Jeanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2262801/
https://ncbi.nlm.nih.gov/pubmed/18023463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2007.09.012
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