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Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins

Abstract Dinoflagellates and cyanobacteria produce saxitoxin (STX) and ~50 congeners that disrupt bioelectrical signals by blocking voltage-gated sodium channels (NaVs). Consuming seafood carrying these toxins causes paralytic shellfish poisoning (PSP). Although NaVs and anuran STX binding proteins...

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Hoofdauteurs: Sandra Zakrzewska, Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, J. Du Bois, Daniel L. Minor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Portfolio 2025-04-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-025-58903-2
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