Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness

Hyperkalemic periodic paralysis (HyperKPP) produces myotonia and attacks of muscle weakness triggered by rest after exercise or by K(+) ingestion. We introduced a missense substitution corresponding to a human familial HyperKPP mutation (Met1592Val) into the mouse gene encoding the skeletal muscle v...

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書誌詳細
主要な著者: Hayward, Lawrence J., Kim, Joanna S., Lee, Ming-Yang, Zhou, Hongru, Kim, Ji W., Misra, Kumudini, Salajegheh, Mohammad, Wu, Fen-fen, Matsuda, Chie, Reid, Valerie, Cros, Didier, Hoffman, Eric P., Renaud, Jean-Marc, Cannon, Stephen C., Brown, Robert H.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2008
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2260907/
https://ncbi.nlm.nih.gov/pubmed/18317596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32638
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