Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness

Hyperkalemic periodic paralysis (HyperKPP) produces myotonia and attacks of muscle weakness triggered by rest after exercise or by K(+) ingestion. We introduced a missense substitution corresponding to a human familial HyperKPP mutation (Met1592Val) into the mouse gene encoding the skeletal muscle v...

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Detalhes bibliográficos
Main Authors: Hayward, Lawrence J., Kim, Joanna S., Lee, Ming-Yang, Zhou, Hongru, Kim, Ji W., Misra, Kumudini, Salajegheh, Mohammad, Wu, Fen-fen, Matsuda, Chie, Reid, Valerie, Cros, Didier, Hoffman, Eric P., Renaud, Jean-Marc, Cannon, Stephen C., Brown, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2260907/
https://ncbi.nlm.nih.gov/pubmed/18317596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32638
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