Aromatic Amino Acids in the Juxtamembrane Domain of Severe Acute Respiratory Syndrome Coronavirus Spike Glycoprotein Are Important for Receptor-Dependent Virus Entry and Cell-Cell Fusion

The severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein (S) is a class I viral fusion protein that binds to its receptor glycoprotein, human angiotensin converting enzyme 2 (hACE2), and mediates virus entry and cell-cell fusion. The juxtamembrane domain (JMD) of S is an aroma...

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Detalhes bibliográficos
Main Authors: Howard, Megan W., Travanty, Emily A., Jeffers, Scott A., Smith, M. K., Wennier, Sonia T., Thackray, Larissa B., Holmes, Kathryn V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258972/
https://ncbi.nlm.nih.gov/pubmed/18199653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01805-07
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