Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance

Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subj...

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Hlavní autoři: Yerly, Daniel, Heckerman, David, Allen, Todd M., Chisholm, John V., Faircloth, Kellie, Linde, Caitlyn H., Frahm, Nicole, Timm, Joerg, Pichler, Werner J., Cerny, Andreas, Brander, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258967/
https://ncbi.nlm.nih.gov/pubmed/18184704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02252-07
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